The outbreak of COVID-19 has driven the rapid development of mRNA vaccine technology. Compared with traditional inactivated and attenuated vaccines, mRNA only expresses specific antigens and induces directional immune responses, which has a high effective protection rate. Due to the advantages of efficacy, safety and fast production, mRNA vaccine has become a star product in the field of medical science and technology innovation. During the production of mRNA vaccine, large-scale purification of plasmid DNA and mRNA vaccine is a key factor affecting the efficacy of mRNA vaccine.
mRNA Vaccine Production Process
Purification media for plasmid
Focurose 6FF
Product Name | Seperation range (Globulin) | Particle size range | Average particle size | Withstand stress | Maximum flow rate | PH stability | Application |
Focurose 6FF | 1×10⁴- 4×10⁶ | 45-165μm | 90μm | ≤0.3Mpa | 700cm/h | 2-12(Long term） 2-14(Short term） | Determination of biological macromolecular weight such as protein and polysaccharide；Plasmid DNA, virus, vaccine purification |
Affinity media for plasmid purification
Product Name | Capacity mg/ml(Media) | Particle size range | Withstand stress | Maximum flow rate | PH stability | Application |
Plasmid Focurose HPR | 2mg(pDNA) | 25-45μm | ≤0.5Mpa | 220cm/h | 3-11(Short term） 2-13(Long term） | pDNA Isolation and purification |
Plasmid Focurose HF | 2mg(pDNA) | 45-165μm | ≤0.5Mpa | 700cm/h |
Multi-mode chromatography media
Product Name | Particle size range | Average Particle size | Withstand stress | Maximum flow rate | PH stability | Application |
Focore 700 | 45-165μm | 90μm | ≤0.5Mpa | 700cm/h | 2-14(Short term） 4-12(Long term） | For flow-through purification of viruses, virus-like particles, virus vectors, etc. |
Focore 400 | 45-165μm | 90μm | ≤0.5Mpa | 700cm/h |
Q Focurose HPR
Product Name | Ion Load μmol/ml | Average Particle size | Withstand stress | Maximum flow rate | PH stability | Application |
| Q Focurose HPR | 130-160 Cl- | 25-45μm | ≤0.5Mpa | ≥220cm/h | 2-14(Short term） 4-12(Long term） | High flow rate and high capacity; High resolution and high recovery. Efficient purification of vaccines, viruses, proteins. |
Phenyl Focurose FF
Product Name | Ligand concentration μmol/ml | Average Particle size | Withstand stress | Maximum flow rate | PH stability | Application |
Phenyl Focurose FF(LS） | 20 | 45-165μm | ≤0.3Mpa | 700cm/h | 2-14(Short term） 3-13(Long term） | Separation and purification of various proteins, suitable for the purification of substances containing aromatic groups, and further purification after desalting. |
Phenyl Focurose FF(HS） | 40 | 45-165μm | ≤0.3Mpa | 700cm/h |
Chromatography Media for mRNA Purication
mRNA Purification Media
Product Name | Ligand concentration mg/ml Media | Average Particle size | Withstand stress | Maximum flow rate | PH stability | Application |
Focurose dT30 | 4mg/ml Media | 45-165μm | ≤0.3Mpa | 100-300cm/h | 3-11(Short term） 2-13(Long term） | Separation and purification of mRNA |
Q Focurose HPR | 130-160 Cl- | 25-45μm | ≤0.5Mpa | ≥220cm/h |
Ordering Information:
Category | Product Name | Size | Price |
Plasmid Purification Media | Focurose 6FF | 25ml/100ml/500ml /1L/5L/20L | |
Plasmid Focurose HPR | |||
Plasmid Focurose HF | |||
Focore 700 | |||
Q Focurose HPR | |||
Phenyl Focurose FF(LS) | |||
Phenyl Focurose FF(HS) | |||
Preloaded Columns with Plasmid Purification Media | HT Focurose 6FF | 1ml/5ml | |
HT Plasmid Focurose HPR | |||
HT Plasmid Focurose HF | |||
HT Focore 700 | |||
HT Q Focurose HPR | |||
HT Phenyl Focurose FF(LS) | |||
HT Phenyl Focurose FF(HS) | |||
mRNA Purification | Focurose dT30 | 25ml/100ml/500ml /1L/5L/20L | |
Oligo dT Magnetic Microspheres (1μm) | 10ml/100ml |
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